The SIG P245 variant of the P220 is chambered only in .45 ACP (deriving its name) and was produced and developed primarily for the United States market as a police backup weapon, or a civilian's concealed sidearm.
The SIG P245 has a standard reversible magazine release. This gives the user the choice of operating it with their right or left thumb.
The weapon normally takes 6 round magazines, but can also accept the 7, 8, or 10 round magazines specifically designed for the 220. A custom grip extender is always available for use with the longer magazines.
SIG no longer manufactures the P245 because the weapon has been replaced by the 220 Carry and then more recently by the 220 Compact.