Having no experience with larger caliber semi auto pistol ammo has not been a major handicap. However I have learned a few things from my limited exposure to the .45ACP cartridge.
#1- Loading mixed brass in a vibratory cleaner is ok as long as the calibers are near to identical. (.380, 9mm, .38, .357) .45s are the big fish in the small pool. They will swallow anything they can fit in their mouth. Sometimes it takes a bit of work to extract a .380 from a .45 with all the media lodged in there.
#2- seeing a light charge of powder in a smaller case is easy. Seeing a light charge in a large case isn't. I bought a pound of titiegroup on the reccomendation of many folks (Reaper included) and so far it has been excellent. The .38 SPL takes about 3 grains, easy enough to verify a charged case. The .45 takes just over 4 grains, barely covers the bottom of the case. I'm gonna mount a new light to shine more or less directly in the case as it sits below the seating die. Then a lean forward and glance will verify a charged case.
#3- Just because you can clean 200 .38s at a time don't mean you can clean 200 .45s.
I guess the girls are right. Length is one thing, girth is a whole different story.
The cartridges in the pic are reloads I've made.
Lead cast conical from Bullet Works 225 gr
4.2 grains of Titegroup powder
CCI large pistol primers.
Easy on the recoil and the pocketbook.
I fired a couple of "boxes" a while back and cleaning the pistol was no problem. 3 patches wet with solvent, bore snake and 2 dry patches came out clean. No lead deposits whatsoever.